Tasks and Tools
Radiation-Sensitive UCA Design: In collaboration with the Physical Chemistry of Macromolecules lab of TorVergata and DoseVue NV, IMEC’s OBPC team will design and develop radiation sensitive UCA formulations. In particular, this group will focus on lipid shelled EMBs.
Shell Derivatisation: The lab will modify the shell of their UCA devices to enable binding of tumour targeting ligands and imaging probes.
Physico-Chemical Characterisation: In collaboration with the Physical Chemistry of Macromolecules lab of Tor Vergata, the lab will actively work on the physico-chemical characterisation of UCAs to assess and quantify their radiation-sensitivity, and to reveal radiation-sensitising mechanisms.
UCA Production: The lab will investigate UCA production techniques (sonication/microfluidics).
Infrastructure and Technical Equipment:
- Equipment for chemical solution synthesis, synthesis lab fully equipped.
- Sonicators (different modules), microfluidic systems for microbubble production
- All characterisation equipments relevant to our tasks in the project:
- Quartz crystal microbalance (QCM-D)
- Atomic force microscopy
- Optical microscopy
- Laser diffraction particle analyser
- Scanning electron microscopy
- X-ray photoelectron spectroscopy
- FTIR (Fourier transform infrared spectroscopy)
- UV VIS spectroscopy
- Raman Spectroscopy
- Solid state NMR (nuclear magnetic resonance): liquid, solid state