Tasks and Tools
The lab of Physical Chemistry of Macromolecules will focus on:
Radiation-Sensitive UCA Design: In collaboration with IMEC and DoseVue NV, Tor Vergata will design and develop radiation sensitive UCA formulations. In particular, this group will focus on polymer shelled EMBs, as well as on radiation sensitive (reversible and irreversible) AVDs.
Shell Derivatisation: Tor Vergata will modify the shell of their UCA devices to enable binding of tumour targeting ligands and imaging probes.
Physico-Chemical Characterisation: Tor Vergata will actively work on the physico-chemical characterisation to assess and quantify their radiation-sensitivity, and to reveal radiation-sensitising mechanisms.
The laboratory is equipped with all relevant infrastructure to conduct its planned research activities, including several types of microscopes (AFM, FE-SEM, Confocal Microscopy), spectroscopes (NMR,IR, Raman, Circular dichroism, Uv-vis, FACS), scattering methods and standard analytical methods.